Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sex
Jie Z. Hawes, Austin J. Cocciolone, Amy H. Cui, Diana B. Griffin, Marius C. Staiculescu, Robert P. Mecham, Jessica E. Wagenseil
Abstract
A comprehensive study on arterial mechanical behavior as a function of elastin content, aging, and sex in mice. Elastin haploinsufficient arteries start at a different homeostatic set point for mechanical parameters such as circumferential stress, stretch, and material stiffness. Structural stiffness of the arterial wall greatly increases with aging, as expected, but there are interactions between sex and aging for most of the mechanical parameters that are important to consider in future work.
Topics & Concepts
HaploinsufficiencyElastinInternal medicineCardiologyMedicineBiologyPathologyGeneticsPhenotypeGeneCardiovascular Health and Disease PreventionCerebrovascular and Carotid Artery DiseasesConnective tissue disorders research