Naringenin prolongs lifespan and delays aging mediated by IIS and MAPK in <i>Caenorhabditis elegans</i>
Yue Ge, Huibin Chen, Jilite Wang, Guishan Liu, Steve W. Cui, Ji Kang, Yumei Jiang, Hao Wang
Abstract
. Moreover, the selected mutant strains were used and molecular docking was conducted to further suggest that IIS and MAPK pathways could be involved in the NN-mediated longevity-promoting effect.
Topics & Concepts
NaringeninCaenorhabditis elegansAntioxidantOxidative stressChemistryDownregulation and upregulationReactive oxygen speciesMAPK/ERK pathwayCell biologyCTL*BiochemistrySignal transductionBiologyIn vitroFlavonoidGeneCytotoxic T cellGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatonin