Distinct responses between healthy and cirrhotic human livers upon lipopolysaccharide challenge: possible implications for acute-on-chronic liver failure
Su Suriguga, Mei Li, Theerut Luangmonkong, Miriam Boersema, Koert P. de Jong, Dorenda Oosterhuis, Arko Gorter, Leonie Beljaars, Peter Olinga
2022American Journal of Physiology-Gastrointestinal and Liver Physiology13 citationsDOIOpen Access PDF
Abstract
Precision-cut liver slices (PCLSs) model provides a unique platform to investigate the different immune responses of healthy versus cirrhotic livers in humans. Our data show that cirrhotic PCLSs exhibit excessive inflammatory response accompanied by a lower anti-inflammatory cytokine release in response to LPS; a better understanding of this alteration may guide the novel therapeutic approaches to mitigate the excessive inflammation during the onset of acute-on-chronic liver failure.
Topics & Concepts
Proinflammatory cytokineCXCL1CirrhosisMedicineImmune systemLipopolysaccharideCytokineImmunologyTumor necrosis factor alphaInflammationInternal medicineChemokineLiver Disease and TransplantationLiver Disease Diagnosis and TreatmentDrug-Induced Hepatotoxicity and Protection