A dual-responsive polyurethane nanocarrier for drug release triggered by intracellular GSH and NQO1 enzyme
Shuai Yang, Jinhai Xie, Dongdong Wang, Shuangyu Tian, Yaodong Di, Lesan Yan
Abstract
A dual-responsive polyurethane nanocarrier was developed to achieve specific and efficient drug release triggered by elevated glutathione levels and the NQO1 enzyme unique to tumor sites.
Topics & Concepts
NanocarriersIntracellularChemistryGlutathioneEnzymePolyurethaneDrugDual (grammatical number)PharmacologyBiochemistryMedicineOrganic chemistryArtLiteratureSynthesis and Characterization of Heterocyclic CompoundsNanoplatforms for cancer theranosticsEnzyme function and inhibition