The Role of Five Key Minerals (Cu, Se, Zn, Co, Fe) in Reproductive Function of Female Cattle: Current Insights and Future Directions
Bo Wang, Xinlin Li, Zimo Zhou, Yanqiu Zhu, Zhicai Zuo, Hongrui Guo
Abstract
Reproductive efficiency in female cattle is significantly influenced by micronutrient status, particularly the availability and balance of essential trace minerals. Selenium, copper, zinc, cobalt, and iron serve as critical components of enzymatic systems, antioxidant defense networks, hormone synthesis, and cellular metabolism, collectively sustaining reproductive health. This review integrates current research evidence on the physiological functions and molecular mechanisms through which these five trace minerals regulate reproductive performance in female cattle, with a specific focus on iron-an often overlooked element-highlighting the novelty of this synthesis. Both deficiency and excess of these minerals impair key reproductive outcomes such as estrous cyclicity, conception rate, and embryonic survival. Furthermore, complex interactions among minerals influence their bioavailability and physiological responses. Advances in mineral supplementation strategies, particularly the application of organic minerals and precision feeding technologies, offer promising solutions to improve reproductive performance. Elucidating these interrelationships provides a theoretical foundation for optimizing trace mineral nutrition, thereby enhancing female cattle fertility, reducing metabolic disorders and promoting the sustainable development of beef and dairy industries.