Functionalized resorcinarenes effectively disrupt the aggregation of αA66-80 crystallin peptide related to cataracts
Kwaku Twum, Avik Bhattacharjee, Erving T. Laryea, Josephine Esposto, George Omolloh, Shaelyn Mortensen, Maya Jaradi, Naomi L. Stock, Nicholas Schileru, Bianca Elias, Elan Pszenica, Theresa M. McCormick, Sanela Martić, Ngong Kodiah Beyeh
Abstract
extended aromatic interactions. These results highlight the potential of versatile and tunable functionalized resorcinarenes as potential therapeutics to reverse the aggregation of α-crystallin dominant in eye cataracts.
Topics & Concepts
PeptideChemistryCrystallinReceptorCationic polymerizationCombinatorial chemistryCovalent bondStereochemistryBiophysicsBiochemistryOrganic chemistryBiologyConnexins and lens biologyImmune Response and InflammationS100 Proteins and Annexins