Design and synthesis of novel glycyrrhetinic acid-triazole derivatives that exert anti-plasmodial activity inducing mitochondrial-dependent apoptosis in <i>Plasmodium falciparum</i>
Deepak Singh Kapkoti, Saurabh Kumar, Ashish Kumar, Mahendra P. Darokar, Anirban Pal, Rajendra Singh Bhakuni
Abstract
Malaria is an enormous threat to public health due to the emergence of Plasmodium falciparum resistance to widely used anti-malarials, such as chloroquine.
Topics & Concepts
Plasmodium falciparumChemistryChloroquineMalariaApoptosisPlasmodium (life cycle)TriazoleMitochondrionPharmacologyCell biologyBiochemistryParasite hostingImmunologyOrganic chemistryBiologyWorld Wide WebComputer sciencePharmacological Effects of Natural CompoundsPhytochemistry and Bioactivity StudiesQuinazolinone synthesis and applications