Copper-Catalyzed Diamination of Unactivated Alkenes With Electron-Rich Amino Sources
Yang Li, Arshad Ali, Junchao Dong, Yu Zhang, Lili Shi, Qun Liu, Junkai Fu
Abstract
The catalytic intermolecular diamination of unactivated alkenes with electron-rich amino sources is a challenge. Herein, by employing a directing-group strategy, a copper-catalyzed diamination of unactivated alkenes was realized. Symmetrical diamines were efficiently produced in a highly diastereoselective manner with readily available dialkylamines as amino sources, while a one-pot and two-step operation was necessary to produce the unsymmetrical diamines. These reactions were proposed to proceed through aziridinium intermediates.
Topics & Concepts
ChemistryCatalysisIntermolecular forceCopperCombinatorial chemistryAminationFunctional groupOrganic chemistryMoleculePolymerSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis