Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ
Michael C. Myers, Donna M. Bilder, Cullen L. Cavallaro, Hannguang J. Chao, Shun Su, Neil T. Burford, Akbar Nayeem, Tao Wang, Mujing Yan, Robert A. Langish, Marta Dabros, Yixin Li, Anne Rose, Kamelia Behnia, Joelle M. Onorato, Peter S. Gargalovic, Ruth R. Wexler, R. Michael Lawrence
Topics & Concepts
PyrimidinonesChemistryG protein-coupled receptorApelinArylAgonistPharmacologyDrug discoverySmall moleculeCombinatorial chemistryStereochemistryReceptorBiochemistryOrganic chemistryMedicineAlkylApelin-related biomedical researchHormonal Regulation and HypertensionCardiovascular, Neuropeptides, and Oxidative Stress Research