“One-Shot” Measurement of Residual Chemical Shift Anisotropy Using Poly-γ-benzyl-<scp>l</scp>-glutamate as an Alignment Medium
Michael J. J. Recchia, Ryan D. Cohen, Yizhou Liu, Edward C. Sherer, James K. Harper, Gary E. Martin, R. Thomas Williamson
Abstract
A method for the measurement of residual chemical shift anisotropy in one experiment using a biphasic isotropic/anisotropic lyotropic liquid crystalline medium based on poly-γ-benzyl-l-glutamate as the alignment medium is presented. This approach is demonstrated on the model compound strychnine and neotricone, a depsidone natural product with a questionable structural assignment based on comparison with the closely related excelsione and in-depth density functional theory calculations.
Topics & Concepts
ChemistryAnisotropyIsotropyGlutamate receptorDensity functional theoryChemical engineeringComputational chemistryOpticsBiochemistryPhysicsEngineeringReceptorMolecular spectroscopy and chiralityAxial and Atropisomeric Chirality SynthesisAnalytical Chemistry and Chromatography