Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk, Paolo Vignali, B. Rhodes Ford, Natalie Rittenhouse, Ronal M. Peralta, Yiyang Wang, Yupeng Wang, Kristin DePeaux, Amanda C. Poholek, Greg M. Delgoffe
Topics & Concepts
Cell biologyBiologyHypoxia (environmental)StimulationReactive oxygen speciesT cellMitochondrionReprogrammingCellCancer researchImmune systemImmunologyChemistryEndocrinologyBiochemistryOxygenOrganic chemistryImmune Cell Function and InteractionCancer, Hypoxia, and MetabolismImmune cells in cancer