Prenylated phenolic compounds from licorice (<i>Glycyrrhiza uralensis</i>) and their anti-inflammatory activity against osteoarthritis
Lu Zhao, Xiaofei Chen, Xian Shao, Ziyu Wang, Yan Du, Cuicui Zhu, Wei Du, Daoquan Tang, Shuai Ji
Abstract
. Compound 2 (glycyuralin R) was a racemic 3-phenoxy-chromanone, and we achieved its chiral separation for the first time. Compounds 1, 2, 7 and 8 showed significant NO inhibitory ability in IL-1β-stimulated mouse primary chondrocytes, and we further confirmed the anti-inflammatory activity of 1 (glycyuralin Q) by evaluating its effect on osteoarthritis-related iNOS, COX-2, TNF-α, IL-6, MMP3, MMP13 and NF-κB based on various experimental methods. These results clarified the potential of several prenylated phenolic compounds, especially 1 in licorice, as the lead compounds for osteoarthritis.
Topics & Concepts
Glycyrrhiza uralensisGlycyrrhizaTraditional medicineOsteoarthritisChemistryPharmacologyMedicinePathologyAlternative medicinePharmacological Effects of Natural CompoundsNatural product bioactivities and synthesisChromatography in Natural Products