Cefiderocol Retains Antibiofilm Activity in Multidrug-Resistant Gram-Negative Pathogens
Christine Pybus, Christina F. Felder-Scott, Victor C Obuekwe, David E. Greenberg
Abstract
< 0.0001) superior to that seen with the other antibiotics (49% to 82%). Cefiderocol was generally as effective as or superior to the other antibiotics, depending on the pathogen-antibiotic combination, in reducing biofilm in other pathogens. There was a trend toward greater biofilm reduction seen with increased antibiotic dose or with increased frequency of antibiotic treatment. We conclude that cefiderocol effectively reduces biofilm and is a potent inhibitor of planktonic growth across a range of Gram-negative medically important pathogens.
Topics & Concepts
Multiple drug resistanceGramBiologyMicrobiologyGram-negative bacteriaGram-negative bacterial infectionsComputational biologyDrug resistanceBacteriaAntibioticsEscherichia coliGeneticsGeneAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus