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Design, synthesis, and pharmacological evaluation of novel 1,2,4-triazol-3-amine derivatives as potential agonists of GABAA subtype receptors with anticonvulsant and hypnotic effects

Reza Jahani, Seyed Reza Abtahi, Manijeh Nematpour, Hossein Fasihi Dastjerdi, Mohsen Chamanara, Zahra Hami, Babak Paknejad

2020Bioorganic Chemistry23 citationsDOI

Topics & Concepts

GABAA receptorFlumazenilChemistryPharmacologyAnticonvulsantED50HypnoticZolpidemBenzodiazepineAgonistReceptorAntagonistStereochemistryBiochemistryEpilepsyMedicineNeurosciencePsychologyInsomniaNeuroscience and Neuropharmacology ResearchPhenothiazines and Benzothiazines Synthesis and ActivitiesPharmacological Receptor Mechanisms and Effects
Design, synthesis, and pharmacological evaluation of novel 1,2,4-triazol-3-amine derivatives as potential agonists of GABAA subtype receptors with anticonvulsant and hypnotic effects | Litcius