Design of Dual Inhibitors of Histone Deacetylase 6 and Heat Shock Protein 90
Luca Pinzi, Rosaria Benedetti, Lucia Altucci, Giulio Rastelli
Abstract
tests demonstrated that some of the selected candidates are able to selectively inhibit HDAC6 over HDAC1, to increase the acetylation levels of tubulin on cell assays and to reduce cell proliferation. The discovered compounds represent valuable starting points for further hit optimization.
Topics & Concepts
HDAC6AcetylationHDAC1Histone deacetylaseHeat shock proteinHDAC8ChemistryHsp90HistoneIn vitroCell biologyComputational biologyBiochemistryCancer researchBiologyGeneHistone Deacetylase Inhibitors ResearchPeptidase Inhibition and AnalysisCholinesterase and Neurodegenerative Diseases