Mucoadhesive-to-penetrating controllable peptosomes-in-microspheres co-loaded with anti-miR-31 oligonucleotide and Curcumin for targeted colorectal cancer therapy
Ran Zhao, Sujuan Du, Ying Liu, Cong Lv, Yongli Song, Xinchun Chen, Bing Zhang, Dan Li, Shan Gao, Wei Cui, Maksim V. Plikus, Xiaohua Hou, Kaichun Wu, Zhanju Liu, Zhihua Liu, Yingzi Cong, Yuan Li, Zhengquan Yu
Abstract
sOKGM-PS-miR-31i/Cur microspheres are effective rectal delivery system with combined advantages of mucoadhesive and mucus-penetrating properties, representing a potent and viable therapeutic approach for CRC.
Topics & Concepts
CurcuminMicrosphereOligonucleotideColorectal cancerCancer researchCancerTargeted therapyMedicineChemistryPharmacologyInternal medicineChemical engineeringDNABiochemistryEngineeringRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery