Hydrogen Transfer-Mediated Multicomponent Reaction for Direct Synthesis of Quinazolines by a Naphthyridine-Based Iridium Catalyst
Zhenda Tan, Zhongxin Fu, Jian Yang, Yang Wu, Liang Cao, Huanfeng Jiang, Juan Li, Min Zhang
Abstract
O as the sole by-product, which endows a new platform for direct access to valuable quinazolines. Mechanistic investigations suggest that the non-coordinated N-atom in the ligand serves as a side arm to significantly promote the condensation process by hydrogen bonding.
Topics & Concepts
IridiumCatalysisChemistryCombinatorial chemistryOrganic chemistryQuinazolinone synthesis and applicationsAsymmetric Hydrogenation and CatalysisMicrowave-Assisted Synthesis and Applications