Inferring Subsystem Efficiencies in Bipartite Molecular Machines
Matthew Leighton, David A. Sivak
Abstract
Molecular machines composed of coupled subsystems transduce free energy between different external reservoirs, in the process internally transducing energy and information. While subsystem efficiencies of these molecular machines have been measured in isolation, less is known about how they behave in their natural setting when coupled together and acting in concert. Here, we derive upper and lower bounds on the subsystem efficiencies of a bipartite molecular machine. We demonstrate their utility by estimating the efficiencies of the F_{o} and F_{1} subunits of ATP synthase and that of kinesin pulling a diffusive cargo.
Topics & Concepts
Bipartite graphMolecular machineMolecular motorEnergy (signal processing)Computer sciencePhysicsBiological systemProcess (computing)Statistical physicsTopology (electrical circuits)Quantum mechanicsCombinatoricsNanotechnologyTheoretical computer scienceMaterials scienceMathematicsBiologyGraphOperating systemAdvanced Thermodynamics and Statistical MechanicsATP Synthase and ATPases ResearchNanopore and Nanochannel Transport Studies