Palladium-catalyzed asymmetric (4 + 3) cycloaddition of <i>N</i>-2,2,2-trifluoroethylisatin ketimines: access to optically active spirooxindoles
Yinggao Meng, Manman Song, Yue Wang, Yuxin Wang, Er‐Qing Li
Abstract
Herein, we disclose the first Pd-catalyzed enantioselective (4 + 3) cycloaddition of N -2,2,2-trifluoroethylisatin ketimines with 2-methylidenetrimethylene carbonate.
Topics & Concepts
ChemistryCycloadditionEnantioselective synthesisOptically activeCatalysisPalladiumCombinatorial chemistryMedicinal chemistryOrganic chemistryStereochemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis