Bupivacaine Induces ROS-Dependent Autophagic Damage in DRG Neurons via TUG1/mTOR in a High-Glucose Environment
Luying Lai, Yongwei Wang, Shenghui Peng, Wenjing Guo, Guanshan Wei, Le Li, Zhengyuan Xia, Fengxian Li, Shiyuan Xu
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayNeurotoxicityReactive oxygen speciesCell biologyDorsal root ganglionDownregulation and upregulationChemistryMechanistic target of rapamycinProgrammed cell deathLysosomePharmacologyApoptosisBiologySignal transductionBiochemistryNeuroscienceToxicitySpinal cordGeneEnzymeOrganic chemistryAutophagy in Disease and TherapySirtuins and Resveratrol in MedicineCardiac Ischemia and Reperfusion