A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging
Hong Liang, Qunjie Bi, Ao Hu, Xiaobing Chen, Rongrong Jin, Xu Song, Bowen Ke, Matthias Barz, Yu Nie
Abstract
A novel platform rationally integrating indocyanine green analogues and an arginine-rich dendritic peptide with both nitroreductase (NTR) and glutathione (GSH) reduction responsive linkers was developed. This multifunctional platform can enable selective and efficient gene delivery and specific turn-on fluorescence imaging in tumors.
Topics & Concepts
NitroreductaseGlutathioneIndocyanine greenChemistryFluorescenceBiophysicsBiochemistryCombinatorial chemistryGeneEnzymeBiologyMedicineOpticsSurgeryPhysicsRNA Interference and Gene DeliveryNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniques