PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy
Yuhong Ma, Wei Wang, Mujiao He, Yunzhu Liu, Caihua Li, Yinan Zhong, Quanmin Bu, Dechun Huang, Hongliang Qian, Wei Chen
Abstract
results showed that MNs@GI effectively regulated glycemic levels within the normal range for approximately 10 h compared to that of only insulin-loaded microneedles (MNs@INS). Consequently, the highly insulin-loaded, multi-responsive, and pH-triggered MN system has tremendous potential for diabetes treatment.
Topics & Concepts
InsulinPhenylboronic acidInsulin deliveryGlycemicDegradation (telecommunications)HydrolysisMaterials scienceVinyl alcoholIn vivoDiabetes mellitusChemistryGluconic acidPharmacologyPolymerInternal medicineMedicineType 1 diabetesBiochemistryEndocrinologyCatalysisOrganic chemistryComputer scienceBiologyTelecommunicationsBiotechnologyAdvancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsBee Products Chemical Analysis