Design, synthesis and molecular docking study of new pyrimidine-based hydrazones with selective anti-proliferative activity against MCF-7 and MDA-MB-231 human breast cancer cell lines
Waleed A. Badawi, Mohamed Samir, Hazem M. Fathy, Tarek M. Okda, Mohamed H. Noureldin, Gamal M. K. Atwa, Omaima M. Aboulwafa
Topics & Concepts
MCF-7ChemistryDocking (animal)Cancer cellStaurosporineCell cultureIC50PyrimidineApoptosisCell growthCell cycleGrowth inhibitionBiochemistryStereochemistryPharmacologyKinaseCancerIn vitroHuman breastProtein kinase CInternal medicineBiologyMedicineNursingGeneticsSynthesis and biological activitySynthesis of heterocyclic compoundsBioactive Compounds and Antitumor Agents