Enantioselective Single and Dual α-C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer
Xinkun Ren, Bo M. Couture, Ningyu Liu, Manjinder S. Lall, Jeffrey T. Kohrt, Rudi Fasan
Abstract
-heterocycles, which should offer new opportunities for the synthesis, discovery, and optimization of bioactive molecules.
Topics & Concepts
Enantioselective synthesisChemistrySurface modificationCombinatorial chemistryCarbeneAmine gas treatingBiocatalysisOrganic synthesisCatalysisOrganic chemistryReaction mechanismPhysical chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions