A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products
Vignesh Palani, Melecio A. Perea, Kristen E. Gardner, Richmond Sarpong
Abstract
]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners.
Topics & Concepts
PyroneIndole testAnnulationChemistryScaffoldCombinatorial chemistryStereochemistryOrganic chemistryCatalysisComputer scienceDatabaseCatalytic C–H Functionalization MethodsChemical synthesis and alkaloidsCatalytic Alkyne Reactions