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New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis

Vinícius Augusto Campos Péret, Rúbia Castro Fernandes Melo Reis, Saulo Fehelberg Pinto Braga, Monique Dias Benedetti, Ivo Santana Caldas, Diogo Teixeira Carvalho, Luiz Felipe de Andrade Santana, Susana Johann, Thiago Belarmino de Souza

2023European Journal of Medicinal Chemistry20 citationsDOI

Topics & Concepts

MiconazoleFluconazoleChemistryAzoleCandida albicansErgosterolLanosterolTriazoleEugenolImidazoleCryptococcus gattiiKetoconazoleStereochemistryMicrobiologyBiochemistryCryptococcusSterolBiologyOrganic chemistryAntifungalCholesterolAntifungal resistance and susceptibilityFungal Infections and StudiesEssential Oils and Antimicrobial Activity
New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis | Litcius