An atlas of human metabolism
Jonathan L. Robinson, Pınar Kocabaş, Hao Wang, Pierre‐Etienne Cholley, Daniel Cook, Avlant Nilsson, Mihail Anton, Raphaël Ferreira, Iván Domenzain, Virinchi Billa, Angelo Limeta, Karl Alex Hedin, Johan Gustafsson, Eduard J. Kerkhoven, Thomas Svensson, Bernhard Ø. Palsson, Adil Mardinoğlu, Lena Hansson, Mathias Uhlén, Jens Nielsen
Abstract
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold for the integrative analysis of omics data. Researchers have developed increasingly comprehensive human GEMs, but the disconnect among different model sources and versions impedes further progress. We therefore integrated and extensively curated the most recent human metabolic models to construct a consensus GEM, Human1. We demonstrated the versatility of Human1 through the generation and analysis of cell- and tissue-specific models using transcriptomic, proteomic, and kinetic data. We also present an accompanying web portal, Metabolic Atlas (https://www.metabolicatlas.org/), which facilitates further exploration and visualization of Human1 content. Human1 was created using a version-controlled, open-source model development framework to enable community-driven curation and refinement. This framework allows Human1 to be an evolving shared resource for future studies of human health and disease.