PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Shu‐Ting Hung, Gabriel Linares, Wen-Hsuan Chang, Yunsun Eoh, Gopinath Krishnan, Stacee Mendonca, Sarah Hong, Yingxiao Shi, Manuel Santana, Chuol Kueth, Samantha Macklin-Isquierdo, Sarah L. Perry, Sarah Duhaime, Claudia Maios, Jonathan Chang, Joscany Perez, Alexander Benavides Couto, Jesse D. Lai, Yichen Li, Samuel V. Alworth, Eric Hendricks, Yaoming Wang, Berislav V. Zloković, Dion Dickman, J. Alex Parker, Daniela C. Zarnescu, Fen‐Biao Gao, Justin K. Ichida
Topics & Concepts
Amyotrophic lateral sclerosisBiologyTARDBPSOD1DiseaseMechanism (biology)C9orf72NeuroscienceAutophagyProtein aggregationUbiquitinGeneticsGeneApoptosisMedicinePathologyAllelePhilosophyEpistemologyTrinucleotide repeat expansionAmyotrophic Lateral Sclerosis ResearchAutophagy in Disease and TherapyNeurogenetic and Muscular Disorders Research