The mechanism of action of indole-3-propionic acid on bone metabolism
Huimin Xu, Yingzhe Luo, Yi An, Xi Wu
Abstract
activation of receptors such as the Aryl hydrocarbon Receptor (AhR) and the Pregnane X Receptor (PXR). This review summarizes the roles and signaling pathways of IPA in bone metabolism and its impact on various bone metabolic disorders. Furthermore, we discuss the therapeutic potential and limitations of IPA in treating bone metabolic diseases, aiming to offer novel strategies for clinical management.
Topics & Concepts
Indole testChemistryPregnane X receptorMetabolismBone remodelingMechanism of actionReceptorMechanism (biology)PharmacologyBiochemistryEndocrinologyMedicineNuclear receptorIn vitroTranscription factorPhilosophyGeneEpistemologyBone Metabolism and DiseasesInflammatory mediators and NSAID effectsDrug Transport and Resistance Mechanisms