Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation
Sarah M. Glass, F. Peter Guengerich
Abstract
observed in steady-state kinetic assays is due to retinoid transfer becoming rate-limiting in the P450 27C1 catalytic cycle. Overall, these results illustrate that, like the CYP26 enzymes involved in retinoic acid metabolism, P450 27C1 interacts with cellular retinoid-binding proteins.
Topics & Concepts
RetinoidRetinoic acidEnzyme kineticsCytochrome P450BiochemistryEnzymeRetinolBiologyChemistryIsozymeActive siteVitaminGeneRetinoids in leukemia and cellular processesPharmacogenetics and Drug MetabolismEstrogen and related hormone effects