RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma
Hui Han, Yu-Cong Sun, Wei Wei, Zixin Huang, Maosheng Cheng, Hongshen Qiu, Juan Wang, Siyi Zheng, Lianlian Liu, Qiang Zhang, Canfeng Zhang, Jieyi Ma, Siyao Guo, Zhaoyu Wang, Zhenpeng Li, Xu Jiang, Shuibin Lin, Qianwen Liu, Shuishen Zhang
Abstract
mRNA in a codon dependent manner. Rescue assays revealed that E-cadherin is an essential downstream target that mediates NSUN6's function in the regulation of ESCC progression. These findings offer additional insights into the link between ESCC and RMGs, as well as provide potential strategies for ESCC management and therapy.
Topics & Concepts
Esophageal squamous cell carcinomaGene knockdownMechanism (biology)RNACancer researchGeneGene signatureBiologyCellCarcinomaOncologyGene expressionMedicineGeneticsPhilosophyEpistemologyRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing