FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate
Kathleen A. Lasick, Elizabeth Jose, Allison Moreno Samayoa, Lisa Shanks, Kelvin W. Pond, Curtis A. Thorne, Andrew L. Paek
Abstract
Both H 2 O 2 and serum starvation activate FOXO transcription factors, but they lead to different FOXO-induced cell outcomes. Here we find a link between the dynamics of FOXO activation and cell fate. H 2 O 2 induces sustained nuclear FOXO, which is linked to cell death, while serum starvation causes pulses of nuclear FOXO and cell-cycle arrest.
Topics & Concepts
BiologyCell fate determinationCell biologyStimulus (psychology)Nuclear transportCell nucleusGeneticsTranscription factorCytoplasmGenePsychologyPsychotherapistFOXO transcription factor regulationGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine