Controllable Skeleton Rearrangement of <scp>3‐Substituted</scp> Cyclobutanones under Basic Conditions<sup>†</sup>
Peng Yan, Qiang Zhou, Jun Chen, Ping Lu
Abstract
Summary of main observation and conclusion Divergent skeleton rearrangements of cyclobutanones under simply basic conditions have been described. The reaction pathway is controlled by the nature of Z group on 3‐substituted cyclobutanones, leading to the formation of various lactones, lactams and acids. Preliminary results on enantioselective reaction were also reported.
Topics & Concepts
ChemistrySkeleton (computer programming)Enantioselective synthesisStereochemistryCatalysisOrganic chemistryComputer scienceProgramming languageAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods