Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3<i>H</i>)‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds
Le‐Cheng Wang, Yu Zhang, Zhengkai Chen, Xiao‐Feng Wu
Abstract
Abstract A procedure on palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3 H )‐ones has been achieved. In this transformation, Mo(CO) 6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale. magnified image
Topics & Concepts
ChemistryPalladiumNitroTrifluoromethylCatalysisReagentCombinatorial chemistryNitro compoundMedicinal chemistryOrganic chemistryAlkylQuinazolinone synthesis and applicationsN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthesis and Biological Evaluation