Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity
Mahmoud A. Ragab, Mohamed Elagawany, Hoda G. Daabees, Al‐Shaimaa F. Ahmed, Eman M. Awad, Cyrielle Billon, Bahaa Elgendy, Khaled A. M. Abouzid, Shaymaa E. Kassab
Topics & Concepts
ChemistryTamoxifenEstrogen receptorSelective estrogen receptor modulatorEstrogenAntagonistEstrogen receptor alphaPharmacologyIC50Cancer researchCancerBreast cancerReceptorInternal medicineIn vitroBiochemistryBiologyMedicineEstrogen and related hormone effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents