Epstein-Barr Virus LMP1-Activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties
Nannan Zhu, Qian Wang, Zhidong Wu, Yan Wang, Mu‐Sheng Zeng, Yan Yuan
Abstract
LMP1 endows NPC to gain cancer stem cell characteristics through activating mTORC1 and mTORC2 pathways. The different mTOR pathways are responsible for distinct tumorigenic features. Rapamycin-insensitive mTORC1 is essential for CSC drug resistance. NPC tumor initiation capacity is mainly attributed to mTORC2 signaling. mTORC1 and mTORC2 coregulate NPC cell migration and invasion. The revelation of the roles of mTOR signaling in NPC CSC establishment has implications for novel therapeutic strategies to treat relapsed and metastatic NPC and achieve durable remission.
Topics & Concepts
mTORC2mTORC1Cancer researchBiologyPI3K/AKT/mTOR pathwayCancer stem cellProtein kinase BStem cellSignal transductionCell biologyViral-associated cancers and disordersHistiocytic Disorders and TreatmentsPI3K/AKT/mTOR signaling in cancer