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Comparison of Frontier Open-Source and Proprietary Large Language Models for Complex Diagnoses

Thomas A. Buckley, Byron Crowe, Raja-Elie E. Abdulnour, Adam Rodman, Arjun K. Manrai

2025JAMA Health Forum16 citationsDOIOpen Access PDF

Abstract

This comparative effectiveness research assesses the performance of newer open-source large language models (LLMs) with that of closed-source proprietary large LLMs.

Topics & Concepts

FrontierMedical diagnosisOpen sourceComputer scienceSource modelNatural language processingProgramming languageMedicineHistoryTheoretical computer scienceSoftwareArchaeologyPathologyTopic ModelingArtificial Intelligence in Healthcare and EducationMachine Learning in Healthcare