Electrostatic adsorptive loading of ciprofloxacin and metronidazole on chitosan nanoparticles to prolong the drug delivery process with preserved antibacterial activities: formulation and characterization
Fatema Tuj Jahura, Farhana Khanam Ferdousi, Abu Hena Mostofa Kamal, Anwar Ul‐Hamid, M. Q. Ehsan, Mohammad Abul Hossain
Abstract
release kinetic studies. Thus, the adsorption of drugs on the surface of CSNPs resulted in the sustained release of the drugs from CSNPs without encapsulation. Positive results of the antibacterial activities of the CP-loaded CSNPs (CP-CSNPs) against both Gram-positive and Gram-negative bacteria were observed.
Topics & Concepts
ChitosanCiprofloxacinMetronidazoleDrug deliveryNanoparticleChemistryDrugAntibacterial activityNanotechnologyPharmacologyMaterials scienceAntibioticsMedicineOrganic chemistryBiochemistryBacteriaBiologyGeneticsAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsPolymer Surface Interaction Studies