PINK1: From Parkinson’s disease to mitophagy and back again
Benjamin O’Callaghan, John Hardy, Hélène Plun‐Favreau
Abstract
The genetics of Parkinson's disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 PLOS Biology paper that shed light on the functional importance of PINK1 in the mitophagy cascade.
Topics & Concepts
BiologyPINK1MitophagyParkinson's diseaseDiseaseLRRK2NeuroscienceGeneticsAutophagyMutationInternal medicineGeneMedicineApoptosisAutophagy in Disease and TherapyParkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research