New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson’s disease
Xingyue Chen, Guoxin Zhang, Miao Liu, Juanfeng He, Zhentao Zhang
Abstract
Exercise offers neuroprotective benefits in Parkinson's disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy. Irisin, a muscle-derived cytokine, links exercise to neuronal health by regulating mitochondria and mitigating oxidative stress. Notably, irisin may serve as a therapeutic target for patients unable to exercise. Thus, exercise is a promising non-pharmacological intervention warranting further research for novel PD therapies.
Topics & Concepts
Parkinson's diseaseNeuroprotectionGlial cell line-derived neurotrophic factorNeurotrophic factorsDiseaseMedicineOxidative stressAutophagyNeuroscienceInflammationPhysical exerciseNeurologyBioinformaticsPharmacologyPhysical therapyPsychologyInternal medicineBiologyApoptosisReceptorBiochemistryAdipose Tissue and MetabolismSirtuins and Resveratrol in MedicineParkinson's Disease Mechanisms and Treatments