Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin
John Ndayishimiye, Yuxue Cao, Tushar Kumeria, Mark A. T. Blaskovich, James R. Falconer, Amirali Popat
Abstract
for un-encapsulated Van) after 3 h. The enhancement was dependent on both the type of SNPs and their surface functionalisation. The permeation enhancing effect of SNPs was due to its ability to transiently open the tight junctions measured by decrease in transepithelial resistance (TEER) which was reversible after 3 h. All in all, our data highlights the potential of SNPs (especially SNPs with large pores) for oral delivery of Van or other antimicrobial peptides.
Topics & Concepts
VancomycinMesoporous silicaDrug deliveryNanoparticleMaterials sciencePermeationNanotechnologyMesoporous materialPharmacologyMedicineChemistryStaphylococcus aureusOrganic chemistryBacteriaBiochemistryMembraneCatalysisGeneticsBiologyDrug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsClostridium difficile and Clostridium perfringens research