Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy
Liguo Wang, Xuejing Shao, Tianbai Zhong, Yue Wu, Aixiao Xu, Xiuyun Sun, Hongying Gao, Yongbo Liu, Tianlong Lan, Yan Tong, Tao Xue, Wenxin Du, Wei Wang, Yingqian Chen, Ting Li, Xianbin Meng, Haiteng Deng, Bo Yang, Qiaojun He, Meidan Ying, Yu Rao
Topics & Concepts
Differentiation therapyComputational biologyClass (philosophy)Cyclin-dependent kinase 2BiologyMedicineComputer scienceGeneticsArtificial intelligenceCell cycleGeneAcute promyelocytic leukemiaRetinoic acidProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways