NSUN2-mediated m<sup>5</sup>C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis
Xiukun Hou, Qiman Dong, Jie Hao, Min Liu, Junya Ning, Mei Tao, Zhongyu Wang, Fengli Guo, Dongmei Huang, Xianle Shi, Ming Gao, Dapeng Li, Xiangqian Zheng
Abstract
These findings suggest that the NSUN2/SRSF6/UAP1 signaling axis plays a vital role in MDR of ATC and identify NSUN2 as a synergistic target for chemotherapy and targeted therapy in ATC.
Topics & Concepts
ReprogrammingMultiple drug resistanceCancerAnaplastic thyroid cancerCancer researchSignal transductionChemistryThyroid cancerBiologyMedicineDrug resistanceInternal medicineGeneticsCellBiochemistryRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms