REPIC: a database for exploring the N6-methyladenosine methylome
Shun Liu, Allen Zhu, Chuan He, Mengjie Chen
Abstract
Abstract The REPIC ( R NA E PI transcriptome C ollection) database records about 10 million peaks called from publicly available m 6 A-seq and MeRIP-seq data using our unified pipeline. These data were collected from 672 samples of 49 studies, covering 61 cell lines or tissues in 11 organisms. REPIC allows users to query N 6 -methyladenosine (m 6 A) modification sites by specific cell lines or tissue types. In addition, it integrates m 6 A/MeRIP-seq data with 1418 histone ChIP-seq and 118 DNase-seq data tracks from the ENCODE project in a modern genome browser to present a comprehensive atlas of m 6 A methylation sites, histone modification sites, and chromatin accessibility regions. REPIC is accessible at https://repicmod.uchicago.edu/repic .