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An environmentally benign cascade reaction of chromone-3-carboxaldehydes with ethyl 2-(pyridine-2-yl)acetate derivatives for highly site-selective synthesis of quinolizines and quinolizinium salts in water

Li Chen, Rong Huang, Kun Li, Xing-Han Yun, Chang-Long Yang, Sheng‐Jiao Yan

2020Green Chemistry38 citationsDOI

Abstract

A protocol for the synthesis of quinolizines from ethyl 2-(pyridine-2-yl)acetates <italic>via</italic> an unprecedented cascade reaction in water was constructed.

Topics & Concepts

ChromoneChemistryPyridineCascadeOrganic chemistryEthyl acetateCombinatorial chemistryChromatographyMulticomponent Synthesis of HeterocyclesSynthesis and Biological EvaluationCatalytic C–H Functionalization Methods
An environmentally benign cascade reaction of chromone-3-carboxaldehydes with ethyl 2-(pyridine-2-yl)acetate derivatives for highly site-selective synthesis of quinolizines and quinolizinium salts in water | Litcius