The gut microbiota contributes to the infection of bovine viral diarrhea virus in mice
Zecai Zhang, Jiang Huang, Chuang Li, Zhicheng Zhao, Yueqi Cui, Xueying Yuan, Xue Wang, Yü Liu, Yulong Zhou, Zhanbo Zhu
Abstract
experiments, which limits the study of its prevention and control strategy and its pathogenic mechanism. In this study, we successfully confirmed the causal relationship between gut microbiota and BVDV infection as well as the potential molecular mechanism based on a mouse model of BVDV infection and a mouse model of gut microbiota dysbiosis. Meanwhile, a mouse model which is more susceptible to BVDV provided in this study lays an important foundation for further research on prevention and control strategy of BVDV and its pathogenesis. In addition, the antiviral effect of butyrate, the metabolites of butyrate-producing bacteria, has been further revealed. Overall, our findings provide a promising prevention and control strategy to treat this infectious disease which is distributed worldwide.