Calreticulin regulates a switch between osteoblast and chondrocyte lineages derived from murine embryonic stem cells
Carlos Pilquil, Zahra Alvandi, Michał Opas
Abstract
), a canonical Wnt pathway antagonist that blocks GSK3β deactivation. The addition of recombinant mDKK1 switched osteogenic ESC differentiation toward chondrogenic differentiation. The results of our study indicate a role for endoplasmic reticulum calcium signaling via calreticulin in the differentiation of ESCs to closely associated osteoblast or chondrocyte lineages.
Topics & Concepts
CalreticulinCell biologyEndoplasmic reticulumNFATBiologyOsteoblastChondrogenesisCellular differentiationDKK1Wnt signaling pathwayStem cellSignal transductionTranscription factorBiochemistryGeneIn vitroSignaling Pathways in DiseaseGenetics and Neurodevelopmental DisordersEndoplasmic Reticulum Stress and Disease