SRGN crosstalks with YAP to maintain chemoresistance and stemness in breast cancer cells by modulating HDAC2 expression
Zhijie Zhang, Ni Qiu, Jiang Yin, Jianlei Zhang, Hao Liu, Wei Guo, Meijun Liu, Ting Liu, Danyang Chen, Kai Luo, Hongsheng Li, Zhimin He, Jinbao Liu, Guopei Zheng
Abstract
: Our findings clarify the roles and mechanisms of SRGN in mediating chemoresistance in breast cancer and suggest its use a potential biomarker for chemotherapeutic response. We believe that novel therapeutic strategies for breast cancer can be designed by targeting the signaling mediated by the crosstalk between SRGN and YAP.
Topics & Concepts
Gene knockdownCancer researchEctopic expressionTransactivationBreast cancerBiologyMicroarray analysis techniquesTranscription factorFlow cytometryCancerGene expressionMolecular biologyCell cultureGeneGeneticsHippo pathway signaling and YAP/TAZUbiquitin and proteasome pathwaysCancer-related gene regulation