Discovery of highly potent and selective EGFRT790M/L858R TKIs against NSCLC based on molecular dynamic simulation
Tingting Yang, Wenjuan Zhang, Shengjie Cao, Shiyang Sun, Xu Cai, Lei Xu, Pengyun Li, Zhibing Zheng, Song Li
Topics & Concepts
T790MChemistryOsimertinibErlotinibEpidermal growth factor receptorPharmacologyEGFR inhibitorsDrug discoveryTyrosine kinasePharmacophoreReceptorBiochemistryGefitinibMedicineLung Cancer Treatments and MutationsCancer therapeutics and mechanismsHER2/EGFR in Cancer Research