Advances in paper-based analytical devices relying on optical detection
Shan Wang, Weijing Chen, An Du, Yajie Kou, Xiaoxu Xu, Di Hu, Zhaoqing Lu
Abstract
Public health emergencies increasingly threaten human health and socio-economic stability, necessitating enhanced monitoring and early warning capabilities to effectively prevent and mitigate public health risks. Real-time detection devices, through precise detection and dynamic monitoring enabled, play a crucial role in preventing disease outbreaks and reduce the spread of harmful substances. Among these, paper-based optical detection devices have emerged as one of the most promising strategies in the field of point-of-care testing (POCT), owing to their advantages such as portability, low cost, foldability, and visual results. This article systematically reviews the research progress and key challenges of paper-based optical detection devices. Firstly, various types of paper-based detection devices are outlined. Then, the optical sensing methods, recognition elements, and their loading techniques involved in these devices are combed in detailed. Subsequently, specific applications of paper-based optical detection devices in detecting foodborne pathogens, viruses, and heavy metals are summarized. Finally, challenges faced by paper-based optical detection devices and their future prospects are also discussed. This perspective offers researchers a unique viewpoint for developing portable and cost-effective paper-based optical detection devices.